2xYT medium recipe

Base: 1 L · pH 7.0 (adjust with NaOH) · Updated 2026-10-01

A richer-than-LB medium used for phage display, protein expression and M13 phage growth.

🧮 Volume calculator
ComponentAmount Final concentration (1X)
Tryptone8 g1.6%
Yeast extract5 g1%
NaCl2.5 g0.5%
Water (distilled)to final volume

Steps

  1. Dissolve in about 80% of the final volume of water.
  2. Adjust to pH 7.0.
  3. Bring to the final volume with water.
  4. Autoclave (121 °C, 20 min). Store at room temperature.

FAQ

How do I make plates?

Add 15 g/L agar before autoclaving.

This is a widely used standard composition. Amounts depend on the hydrate form and purity of your reagents — check the formula weight (FW) on the bottle and follow your institution's safety rules and the manufacturers' instructions.